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BMI1 Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. Component of a PRC1-like complex. Interacts with RING1 and RING2. Interacts vwith CBX7 and CBX8. Interacts with SPOP. Part of a complex consisting of BMI1, CUL3 and SPOP. Interacts with E4F1. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Ligase; Motility/polarity/chemotaxis; Oncoprotein; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 10p12.2
Cellular Component: cytosol; nuclear body; nucleoplasm; nucleus; PcG protein complex; ubiquitin ligase complex
Molecular Function: protein binding; zinc ion binding
Biological Process: hemopoiesis; negative regulation of gene expression, epigenetic; negative regulation of transcription from RNA polymerase II promoter; positive regulation of fibroblast proliferation; positive regulation of ubiquitin-protein ligase activity; regulation of gene expression; segment specification
Reference #:  P35226 (UniProtKB)
Alt. Names/Synonyms: B lymphoma Mo-MLV insertion region 1 homolog; BMI1; BMI1 polycomb ring finger oncogene; flvi-2/bmi-1; MGC12685; murine leukemia viral (bmi-1) oncogene homolog; oncogene BMI-1; PCGF4; Polycomb complex protein BMI-1; polycomb group protein Bmi1; polycomb group ring finger 4; Polycomb group RING finger protein 4; RING finger protein 51; RNF51
Gene Symbols: BMI1
Molecular weight: 36,949 Da
Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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