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ARF6 GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development. Contributes to the regulation of dendritic branching and filopodia extension. Interacts with ARHGAP21, ASAP2, HERC1, PIP5K1C and UACA. Interacts with NCS1/FREQ at the plasma membrane. Interacts with RAB11FIP3 and RAB11FIP4. Interacts with USP6 (via Rab-GAP TBC domain). Interacts with ECM29. Interacts with TBC1D24. Belongs to the small GTPase superfamily. Arf family. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; G protein, monomeric, ARF; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 14q21.3
Cellular Component: cell cortex; cleavage furrow; endocytic vesicle; endosome; filopodium membrane; focal adhesion; membrane; plasma membrane; recycling endosome membrane; ruffle
Molecular Function: GTP binding; GTPase activity; protein binding; thioesterase binding
Biological Process: cell adhesion; cell motility; cortical actin cytoskeleton organization and biogenesis; negative regulation of receptor-mediated endocytosis; positive regulation of actin filament polymerization; regulation of filopodium formation; regulation of Rac protein signal transduction; ruffle organization and biogenesis; vesicle-mediated transport
Reference #:  P62330 (UniProtKB)
Alt. Names/Synonyms: ADP-ribosylation factor 6; ARF6; DKFZp564M0264
Gene Symbols: ARF6
Molecular weight: 20,082 Da
Basal Isoelectric point: 9.04  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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