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Protein Page:

Fos a proto-oncogenic transcription factor of the bZIP family. Dimerizes with proteins of the JUN family, thereby forming the transcription factor complex AP-1. FOS proteins function as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of FOS has also been associated with apoptotic cell death. Expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress and cell injury. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 14q24.3
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; protein heterodimerization activity; transcription factor activity; transcription factor binding
Biological Process: DNA methylation; inflammatory response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription factor activity; regulation of transcription from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway
Reference #:  P01100 (UniProtKB)
Alt. Names/Synonyms: activator protein 1; AP-1; C-FOS; cellular oncogene c-fos; Cellular oncogene fos; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS); FBJ murine osteosarcoma viral oncogene homolog; FOS; G0/G1 switch regulatory protein 7; G0S7; Proto-oncogene c-Fos; v-fos FBJ murine osteosarcoma viral oncogene homolog
Gene Symbols: FOS
Molecular weight: 40,695 Da
Basal Isoelectric point: 4.77  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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