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EFNB2 a type I membrane protein of the ephrin family. A ligand of Eph-related receptor tyrosine kinases EphA3 and EphB4. Ephrins and ephrin receptors mediate numerous developmental processes, particularly in the nervous system. Ephrin-B2 is implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. May play a role in constraining the orientation of longitudinally projecting axons Note: This description may include information from UniProtKB.
Protein type: Ligand, receptor tyrosine kinase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 13q33.3
Cellular Component: focal adhesion; integral to plasma membrane; plasma membrane
Molecular Function: ephrin receptor binding; protein binding
Biological Process: anatomical structure morphogenesis; axon guidance; cell adhesion; cell migration during sprouting angiogenesis; cell-cell signaling; ephrin receptor signaling pathway; positive regulation of cell proliferation; regulation of chemotaxis
Reference #:  P52799 (UniProtKB)
Alt. Names/Synonyms: EFNB2; EPH-related receptor tyrosine kinase ligand 5; ephrin B2; Ephrin-B2; EPLG5; HTK ligand; HTK-L; HTKL; LERK-5; LERK5; ligand of eph-related kinase 5; MGC126226; MGC126227; MGC126228
Gene Symbols: EFNB2
Molecular weight: 36,923 Da
Basal Isoelectric point: 9.04  Predict pI for various phosphorylation states
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