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UGT1A8 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Belongs to the UDP-glycosyltransferase family. 1 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Cofactor and Vitamin Metabolism - retinol; EC; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: endoplasmic reticulum
Molecular Function: enzyme inhibitor activity; fatty acid binding; glucuronosyltransferase activity; protein heterodimerization activity; protein homodimerization activity; retinoic acid binding; steroid binding
Biological Process: coumarin metabolic process; fatty acid metabolic process; flavone metabolic process; negative regulation of fatty acid metabolic process; negative regulation of steroid metabolic process; retinoic acid metabolic process; steroid metabolic process
Reference #:  Q9HAW9 (UniProtKB)
Alt. Names/Synonyms: GNT1; UD18; UDP glucuronosyltransferase 1 family, polypeptide A8; UDP glycosyltransferase 1 family, polypeptide A8; UDP-glucuronosyltransferase 1 family polypeptide A8s; UDP-glucuronosyltransferase 1-8; UDP-glucuronosyltransferase 1-H; UDP-glucuronosyltransferase 1A8; UDPGT; UDPGT 1-8; UGT-1H; UGT1; UGT1*8; UGT1-08; UGT1.8; UGT1A8; UGT1A8S; UGT1H
Gene Symbols: UGT1A8
Molecular weight: 59,742 Da
Basal Isoelectric point: 7.6  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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