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CCL13 Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens. By IL1/interleukin-1 and TNF. Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells. Belongs to the intercrine beta (chemokine CC) family. Note: This description may include information from UniProtKB.
Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11 C|11 49.82 cM
Cellular Component: cell soma; cytoplasm; dendrite; endocytic vesicle; extracellular space; nerve terminal; perikaryon; perinuclear region of cytoplasm; rough endoplasmic reticulum; synapse
Molecular Function: CCR2 chemokine receptor binding; chemokine activity; cytokine activity; G-protein-coupled receptor binding; heparin binding; protein binding
Biological Process: angiogenesis; cellular calcium ion homeostasis; cytokine and chemokine mediated signaling pathway; cytoskeleton organization and biogenesis; eosinophil chemotaxis; G-protein coupled receptor protein signaling pathway; glial cell migration; inflammatory response; killing of cells of another organism; leukocyte migration during inflammatory response; lymphocyte chemotaxis; macrophage chemotaxis; negative regulation of angiogenesis; neutrophil chemotaxis; positive regulation of cell adhesion; positive regulation of cell-cell adhesion; positive regulation of cellular extravasation; positive regulation of collagen biosynthetic process; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; positive regulation of leukocyte mediated cytotoxicity; positive regulation of leukocyte migration; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of synaptic transmission; positive regulation of T cell activation; positive regulation of tumor necrosis factor production; regulation of cell shape; response to heat; response to wounding; transforming growth factor beta receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway
Reference #:  P10148 (UniProtKB)
Alt. Names/Synonyms: AI323594; C-C motif chemokine 2; Ccl2; chemokine (C-C motif) ligand 2; HC11; Je; MCAF; MCP-1; Mcp1; Monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; Monocyte chemotactic protein 1; OTTMUSP00000000786; Platelet-derived growth factor-inducible protein JE; Scya2; Sigje; small inducible cytokine A2; Small-inducible cytokine A2; SMC-CF
Gene Symbols: Ccl2
Molecular weight: 16,326 Da
Basal Isoelectric point: 9.81  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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