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ZFYVE26 Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair. Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A. Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 14q24.1
Cellular Component: centrosome; lysosomal membrane; midbody
Molecular Function: phosphatidylinositol 3-phosphate binding; protein binding
Biological Process: cytokinesis; double-strand break repair via homologous recombination
Disease: Spastic Paraplegia 15, Autosomal Recessive
Reference #:  Q68DK2 (UniProtKB)
Alt. Names/Synonyms: DKFZp686F19106; DKFZp781H1112; FYVE-CENT; KIAA0321; Spastizin; SPG15; ZFY26; ZFYVE26; Zinc finger FYVE domain-containing protein 26; zinc finger, FYVE domain containing 26
Gene Symbols: ZFYVE26
Molecular weight: 284,576 Da
Basal Isoelectric point: 5.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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