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PPP2R4 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activty of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A. Associates with PP2A heterodimeric core enzyme PP2A(D), composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A). Interacts with PPP2CB. Widely expressed. Belongs to the PTPA-type PPIase family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 9q34.11
Cellular Component: cytoplasm; nucleoplasm; nucleus; protein phosphatase type 2A complex
Molecular Function: ATP binding; ATPase activity; peptidyl-prolyl cis-trans isomerase activity; protein binding; protein heterodimerization activity; protein homodimerization activity; protein phosphatase 2A binding; protein phosphatase regulator activity; protein tyrosine phosphatase activator activity; receptor binding
Biological Process: mitotic spindle organization and biogenesis in nucleus; negative regulation of phosphoprotein phosphatase activity; negative regulation of protein amino acid dephosphorylation; positive regulation of apoptosis; positive regulation of phosphoprotein phosphatase activity; positive regulation of protein amino acid dephosphorylation; regulation of phosphoprotein phosphatase activity
Reference #:  Q15257 (UniProtKB)
Alt. Names/Synonyms: MGC2184; Phosphotyrosyl phosphatase activator; PP2A; PP2A phosphatase activator; PP2A subunit B' isoform PR53; PP2A, subunit B'; PP2A, subunit B', PR53 isoform; PPP2R4; PR53; protein phosphatase 2A activator, regulatory subunit 4; protein phosphatase 2A, regulatory subunit B' (PR 53); PTPA; Serine/threonine-protein phosphatase 2A activator; Serine/threonine-protein phosphatase 2A regulatory subunit 4; Serine/threonine-protein phosphatase 2A regulatory subunit B'
Gene Symbols: PPP2R4
Molecular weight: 40,668 Da
Basal Isoelectric point: 5.63  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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