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CALCOCO2 May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion. Part of a complex consisting of CALCOCO2, TAX1BP1 and MYO6. Interacts with GEMIN4. Expressed in all tissues tested with highest expression in skeletal muscle and lowest in brain. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component: autophagic vacuole; cytoplasm; cytosol; intracellular membrane-bound organelle; membrane; nucleus; perinuclear region of cytoplasm
Molecular Function: protein binding; protein homodimerization activity
Biological Process: viral reproduction
Reference #:  Q13137 (UniProtKB)
Alt. Names/Synonyms: Antigen nuclear dot 52 kDa protein; CACO2; calcium binding and coiled-coil domain 2; Calcium-binding and coiled-coil domain-containing protein 2; CALCOCO2; MGC17318; NDP52; Nuclear domain 10 protein 52; Nuclear domain 10 protein NDP52; Nuclear dot protein 52
Gene Symbols: CALCOCO2
Molecular weight: 52,254 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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