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CAPN1 Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Forms a heterodimer with a small (regulatory) subunit (CAPNS1). Ubiquitous. Activated by micromolar concentrations of calcium and inhibited by calpastatin. Belongs to the peptidase C2 family. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protease
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: cytosol; extracellular region; focal adhesion; membrane; plasma membrane
Molecular Function: calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; endopeptidase activity; protein binding
Biological Process: extracellular matrix disassembly; neutrophil degranulation; positive regulation of cell proliferation; proteolysis; regulation of catalytic activity
Disease: Spastic Paraplegia 76, Autosomal Recessive
Reference #:  P07384 (UniProtKB)
Alt. Names/Synonyms: Calcium-activated neutral proteinase 1; Calpain 1; calpain 1, (mu/I) large subunit; Calpain mu-type; calpain, large polypeptide L1; Calpain-1; Calpain-1 catalytic subunit; Calpain-1 large subunit; CAN1; CANP; CANP 1; CANP1; CANPL1; CAPN1; Cell proliferation-inducing gene 30 protein; cell proliferation-inducing protein 30; Micromolar-calpain; muCANP; muCL
Gene Symbols: CAPN1
Molecular weight: 81,890 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Apoptosis Regulation  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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