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TYMS an enzyme in the thymidylate synthase family. Polymorphisms serve as prognostic markers for determining modality of treatment in certain cancers. Genotyping helps predict toxicity to 5-FU-based chemotherapy in patients with colorectal cancer and the response to platinum-based chemotherapy in advanced NSCLC. A common polymorphism is a determinant of red blood cell folate and homocysteine concentrations. Homodimer. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - one carbon pool by folate; DNA repair, damage; EC; Methyltransferase; Mitochondrial; Nucleotide Metabolism - pyrimidine
Chromosomal Location of Human Ortholog: 18p11.32
Cellular Component: cytoplasm; cytosol; mitochondrial inner membrane; mitochondrial matrix; mitochondrion; nucleus
Molecular Function: folic acid binding; thymidylate synthase activity; translation repressor activity, nucleic acid binding
Biological Process: dTMP biosynthetic process; G1/S-specific transcription in mitotic cell cycle; negative regulation of translation; nucleobase, nucleoside and nucleotide interconversion; response to organophosphorus
Reference #:  P04818 (UniProtKB)
Alt. Names/Synonyms: HST422; MGC88736; Thymidylate synthase; thymidylate synthetase; TMS; TS; TSase; TYMS; TYSY
Gene Symbols: TYMS
Molecular weight: 35,716 Da
Basal Isoelectric point: 6.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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