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CETN2 a calcium-binding proteins and is a structural component of the centrosome. Contains 4 EF-hand calcium-binding domains. Highly conserved from algae to humans. Its association with the centrosome suggests that it plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Cell cycle regulation; DNA repair, damage
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: centriole; centrosome; cytosol; intracellular; nucleoplasm
Molecular Function: protein binding
Biological Process: centriole replication; G2/M transition of mitotic cell cycle; nucleotide-excision repair; nucleotide-excision repair, DNA damage recognition; nucleotide-excision repair, DNA duplex unwinding; nucleotide-excision repair, preincision complex assembly; regulation of cytokinesis
Reference #:  P41208 (UniProtKB)
Alt. Names/Synonyms: CALT; caltractin (20kD calcium-binding protein); Caltractin isoform 1; CEN2; centrin, EF-hand protein, 2; Centrin-2; CETN2
Gene Symbols: CETN2
Molecular weight: 19,738 Da
Basal Isoelectric point: 4.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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