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TSPO Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells. Belongs to the TspO/BZRP family. Interacts with BZRAP1. May interact with STAR. Interacts with MOST-1. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Receptor, misc.
Chromosomal Location of Human Ortholog: 22q13.2
Cellular Component: mitochondrial outer membrane
Molecular Function: cholesterol binding; cholesterol transporter activity; protein binding
Biological Process: anion transport; apoptosis; C21-steroid hormone biosynthetic process; cell proliferation; heme biosynthetic process; protein targeting to mitochondrion; regulation of cholesterol transport; steroid metabolic process
Reference #:  P30536 (UniProtKB)
Alt. Names/Synonyms: benzodiazepine peripheral binding site; BZRP; DBI; IBP; MBR; mDRC; Mitochondrial benzodiazepine receptor; PBR; peripheral benzodiazepine receptor; Peripheral-type benzodiazepine receptor; pk18; PKBS; PTBR; RP3-526I14.4; Translocator protein; translocator protein (18kDa); TSPO; TSPOA
Gene Symbols: TSPO
Molecular weight: 18,828 Da
Basal Isoelectric point: 9.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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