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ORC1L Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with CDC6 and KAT7/HBO1. Belongs to the ORC1 family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1p32.3
Cellular Component: cytosol; nuclear chromosome, telomeric region; nuclear origin of replication recognition complex; nucleolus; nucleoplasm; nucleus; origin recognition complex; plasma membrane
Molecular Function: protein binding
Biological Process: DNA replication; DNA replication initiation; G1/S transition of mitotic cell cycle; G1/S-specific transcription in mitotic cell cycle
Disease: Meier-gorlin Syndrome 1
Reference #:  Q13415 (UniProtKB)
Alt. Names/Synonyms: HSORC1; ORC1; ORC1L; origin recognition complex 1; Origin recognition complex subunit 1; origin recognition complex, subunit 1, S. cerevisiae, homolog-like; origin recognition complex, subunit 1-like (yeast); PARC1; Replication control protein 1
Gene Symbols: ORC1
Molecular weight: 97,350 Da
Basal Isoelectric point: 9.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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