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STX1A a type IV membrane protein involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Vesicle
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: cytosol; integral to membrane; neuron projection; plasma membrane; SNARE complex; synaptic vesicle; voltage-gated potassium channel complex
Molecular Function: chloride channel inhibitor activity; kinase binding; myosin binding; protein binding; SNAP receptor activity; SNARE binding
Biological Process: glutamate secretion; intracellular protein transport; neurotransmitter secretion; positive regulation of calcium ion-dependent exocytosis; positive regulation of catecholamine secretion; regulation of insulin secretion; secretion by cell; synaptic vesicle fusion to presynaptic membrane; vesicle docking
Reference #:  Q16623 (UniProtKB)
Alt. Names/Synonyms: HPC-1; Neuron-specific antigen HPC-1; P35-1; STX1; STX1A; SYN1A; syntaxin 1A (brain); Syntaxin-1A
Gene Symbols: STX1A
Molecular weight: 33,023 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
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