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CSK a tyrosine kinase of the Csk family that phosphorylates and inhibits Src family kinases. Specifically phosphorylates Y504 on LCK, which acts as a negative regulatory site. Csk and the phospho-tyrosine phosphatase CD45 reciprocally regulate phosphorylation of the inhibitory tyrosine of the Src family kinases Lck and Fyn during T-cell receptor mediated signaling during thymic development. Note: This description may include information from UniProtKB.
Protein type: Csk family; EC; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of Human Ortholog: 15q24.1
Cellular Component: cytoplasm; cytosol; extracellular exosome; extrinsic component of cytoplasmic side of plasma membrane; intercellular junction; membrane raft; plasma membrane
Molecular Function: ATP binding; identical protein binding; kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; proline-rich region binding; protein binding; protein C-terminus binding; protein phosphatase binding; protein tyrosine kinase activity; receptor binding
Biological Process: adaptive immune response; brain development; cell differentiation; cellular response to peptide hormone stimulus; central nervous system development; epidermal growth factor receptor signaling pathway; innate immune response; negative regulation of bone resorption; negative regulation of cell proliferation; negative regulation of ERK1 and ERK2 cascade; negative regulation of Golgi to plasma membrane protein transport; negative regulation of interleukin-6 production; negative regulation of kinase activity; negative regulation of low-density lipoprotein particle clearance; negative regulation of phagocytosis; oligodendrocyte differentiation; peptidyl-tyrosine autophosphorylation; positive regulation of MAP kinase activity; protein amino acid phosphorylation; regulation of cell proliferation; regulation of cytokine production; T cell costimulation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P41240 (UniProtKB)
Alt. Names/Synonyms: C-Src kinase; c-src tyrosine kinase; CSK; MGC117393; Protein-tyrosine kinase CYL; Tyrosine-protein kinase CSK
Gene Symbols: CSK
Molecular weight: 50,704 Da
Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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