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FGF1 Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Cytokine; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 5q31.3
Cellular Component: cytosol; extracellular region; extracellular space; nucleoplasm
Molecular Function: 1-phosphatidylinositol-3-kinase activity; fibroblast growth factor receptor binding; growth factor activity; heparin binding; integrin binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity
Biological Process: activation of MAPK activity; activation of protein kinase B; anatomical structure morphogenesis; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; multicellular organismal development; phosphoinositide-mediated signaling; positive regulation of angiogenesis; positive regulation of cell division; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cholesterol biosynthetic process; positive regulation of MAP kinase activity; positive regulation of transcription from RNA polymerase II promoter; regulation of phosphoinositide 3-kinase cascade
Reference #:  P05230 (UniProtKB)
Alt. Names/Synonyms: Acidic fibroblast growth factor; aFGF; Beta-endothelial cell growth factor; ECGF; ECGF-beta; ECGFA; ECGFB; endothelial cell growth factor, alpha; endothelial cell growth factor, beta; FGF-alpha; FGF1; FGFA; fibroblast growth factor 1 (acidic); GLIO703; HBGF-1; HBGF1; Heparin-binding growth factor 1
Gene Symbols: FGF1
Molecular weight: 17,460 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
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