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CD10 Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV- inducible elastase activity toward skin preelastic and elastic fibers. Inhibited in a dose dependent manner by opiorphin. Belongs to the peptidase M13 family. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Protease
Chromosomal Location of Human Ortholog: 3q25.2
Cellular Component: axon; brush border; cytoplasm; dendrite; focal adhesion; plasma membrane; secretory granule membrane; synapse; synaptic vesicle
Molecular Function: endopeptidase activity; exopeptidase activity; metalloendopeptidase activity; metallopeptidase activity; peptide binding; protein binding; zinc ion binding
Biological Process: angiotensin maturation; beta-amyloid metabolic process; creatinine metabolic process; kidney development; neutrophil degranulation; peptide metabolic process; proteolysis; sensory perception of pain
Disease: Charcot-marie-tooth Disease, Axonal, Type 2t; Membranous Nephropathy, Susceptibility To; Spinocerebellar Ataxia 43
Reference #:  P08473 (UniProtKB)
Alt. Names/Synonyms: Atriopeptidase; CALLA; CD10; Common acute lymphocytic leukemia antigen; DKFZp686O16152; Enkephalinase; EPN; membrane metallo-endopeptidase; membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; MGC126681; MGC126707; MME; NEP; Neprilysin; Neutral endopeptidase; Neutral endopeptidase 24.11
Gene Symbols: MME
Molecular weight: 85,514 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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