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Protein Page:

CAND1 Enhances transcription from various types of promoters. Regulatory protein that interferes with the assembly of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex and thereby down-regulates ubiquitination of target proteins. Prevents neddylation of CUL1 by physically blocking access to the neddylation site. Disrupts interactions between CUL1 and SKP1 and between CUL1 and F-box proteins. Binds TBP. Part of a complex that contains CUL1 and RBX1. Binds unneddylated CUL1, but cannot bind CUL1 once it has been neddylated. Binds CUL2, CUL3, CUL4A, CUL4B and CUL5. Belongs to the CAND family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 12q14.3-q15
Cellular Component: cullin-RING ubiquitin ligase complex; cytoplasm; cytosol; extracellular region; Golgi apparatus; membrane; nucleoplasm; nucleus; ubiquitin ligase complex
Molecular Function: protein binding
Biological Process: cell differentiation; cellular iron ion homeostasis; negative regulation of catalytic activity; neutrophil degranulation; post-translational protein modification; protein ubiquitination; SCF complex assembly
Reference #:  Q86VP6 (UniProtKB)
Alt. Names/Synonyms: CAND1; cullin-associated and neddylation-dissociated 1; Cullin-associated and neddylation-dissociated protein 1; Cullin-associated NEDD8-dissociated protein 1; DKFZp434M1414; FLJ10114; FLJ10929; FLJ38691; FLJ90441; KIAA0829; p120 CAND1; TBP interacting protein; TBP-interacting protein 120A; TBP-interacting protein of 120 kDa A; TIP120; TIP120A
Gene Symbols: CAND1
Molecular weight: 136,376 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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