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NMDAR2B an NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 12p13.1
Cellular Component: cell junction; cell surface; integral component of plasma membrane; intracellular; neuron projection; NMDA selective glutamate receptor complex; plasma membrane; postsynaptic density; postsynaptic membrane
Molecular Function: extracellular-glutamate-gated ion channel activity; glutamate binding; glutamate-gated calcium ion channel activity; glycine binding; NMDA glutamate receptor activity; protein binding; Ras guanyl-nucleotide exchange factor activity; zinc ion binding
Biological Process: calcium-mediated signaling; ephrin receptor signaling pathway; excitatory postsynaptic potential; glutamate receptor signaling pathway; ionotropic glutamate receptor signaling pathway; learning and/or memory; MAPK cascade; positive regulation of neuron death; protein heterotetramerization; regulation of molecular function; response to ethanol; synaptic transmission; transport
Disease: Epileptic Encephalopathy, Early Infantile, 27; Mental Retardation, Autosomal Dominant 6
Reference #:  Q13224 (UniProtKB)
Alt. Names/Synonyms: Glutamate [NMDA] receptor subunit epsilon-2; glutamate receptor subunit epsilon-2; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; GRIN2B; hNR3; MGC142178; MGC142180; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3; NMDAR2B; NMDE2; NR2B; NR3
Gene Symbols: GRIN2B
Molecular weight: 166,367 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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