Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

SRF a transcription factor of the MADS domain family that binds to the serum response element (SRE). Regulates the transcription of immediate early genes including c-fos. Binds DNA as a multimer, probably a dimer. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Transcription factor
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: protein binding; protein homodimerization activity; transcription factor activity; transcription factor binding
Biological Process: angiogenesis involved in wound healing; cell migration during sprouting angiogenesis; heart development; heart looping; mRNA transcription from RNA polymerase II promoter; muscle maintenance; neuron development; positive regulation of cell differentiation; positive regulation of smooth muscle contraction; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; regulation of smooth muscle cell differentiation; response to cytokine stimulus; response to hormone stimulus; response to hypoxia; response to toxin; transcription from RNA polymerase II promoter; trophectodermal cell differentiation
Reference #:  P11831 (UniProtKB)
Alt. Names/Synonyms: MCM1; Serum response factor; serum response factor (c-fos serum response element-binding transcription factor); SRF
Gene Symbols: SRF
Molecular weight: 51,593 Da
Basal Isoelectric point: 7.83  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene