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CDC25B a member of the MPI phosphatase family. Activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. Shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. At least four transcript variants for this gene exist. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 20p13
Cellular Component: centrosome; cytosol; nucleoplasm; spindle pole
Molecular Function: phosphoprotein phosphatase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity
Biological Process: G2/M transition of mitotic cell cycle; mitotic cell cycle; positive regulation of cell proliferation; positive regulation of cytokinesis; positive regulation of mitotic cell cycle; protein amino acid phosphorylation
Reference #:  P30305 (UniProtKB)
Alt. Names/Synonyms: CDC25B; CDC25HU2; cell division cycle 25 homolog B (S. pombe); cell division cycle 25B; Dual specificity phosphatase Cdc25B; M-phase inducer phosphatase 2; MPIP2
Gene Symbols: CDC25B
Molecular weight: 64,987 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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