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CD19 a cell surface molecule which assembles with the antigen receptor of B lymphocytes. A critical signal transduction molecule that regulates B lymphocyte development, activation, and differentiation. Ligation increases intracellular calcium levels and decreases the threshold for antigen receptor signaling. Germinal center formation is significantly reduced in CD19-deficient mice. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: external side of plasma membrane; extracellular exosome; integral component of plasma membrane; plasma membrane; protein complex
Molecular Function: phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; receptor signaling protein activity
Biological Process: B cell receptor signaling pathway; cell surface receptor signaling pathway; cellular defense response; phosphatidylinositol phosphorylation; positive regulation of protein kinase B signaling; positive regulation of release of sequestered calcium ion into cytosol; regulation of complement activation; regulation of immune response
Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 3
Reference #:  P15391 (UniProtKB)
Alt. Names/Synonyms: B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; B4; CD19; CD19 antigen; CD19 molecule; Differentiation antigen CD19; MGC12802; T-cell surface antigen Leu-12
Gene Symbols: CD19
Molecular weight: 61,128 Da
Basal Isoelectric point: 4.87  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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