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GTF2B General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II. Associates with TFIID-IIA (DA complex) to form TFIID-IIA- IIB (DAB-complex) which is then recognized by polymerase II. Interacts with the transcription elongation factor TCEA2. Interacts with HIV-1 Vpr. Interacts with GPBP1. Interacts with Epstein-Barr virus EBNA2. Belongs to the TFIIB family. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; Nuclear receptor co-regulator; Transcription factor
Chromosomal Location of Human Ortholog: 1p22.2
Cellular Component: nuclear body; nucleoplasm; nucleus; transcription factor TFIID complex
Molecular Function: protein binding; TATA-binding protein binding; thyroid hormone receptor binding; transcription factor binding
Biological Process: positive regulation of viral transcription; RNA elongation from RNA polymerase II promoter; snRNA transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcriptional preinitiation complex assembly
Reference #:  Q00403 (UniProtKB)
Alt. Names/Synonyms: general transcription factor IIB; General transcription factor TFIIB; GTF2B; RNA polymerase II transcription factor IIB; S300-II; TF2B; TFIIB; Transcription initiation factor IIB
Gene Symbols: GTF2B
Molecular weight: 34,833 Da
Basal Isoelectric point: 8.67  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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