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ADRB2 Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 5q32
Cellular Component: clathrin coated vesicle membrane; endosome; endosome membrane; integral to plasma membrane; lysosome; plasma membrane; receptor complex
Molecular Function: beta-amyloid binding; beta2-adrenergic receptor activity; epinephrine binding; norepinephrine binding; potassium channel regulator activity; protein binding; protein complex binding; protein homodimerization activity
Biological Process: adenylate cyclase activation; arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; cell surface receptor linked signal transduction; cell-cell signaling; endosome to lysosome transport; G-protein signaling, coupled to cAMP nucleotide second messenger; negative regulation of smooth muscle contraction; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure; positive regulation of MAPKKK cascade; positive regulation of protein ubiquitination; protein deubiquitination; receptor-mediated endocytosis; transmembrane receptor protein tyrosine kinase activation (dimerization)
Disease: Asthma, Susceptibility To; Obesity
Reference #:  P07550 (UniProtKB)
Alt. Names/Synonyms: ADRB2; ADRB2R; ADRBR; adrenergic, beta-2-, receptor, surface; B2AR; BAR; Beta-2 adrenergic receptor; Beta-2 adrenoceptor; Beta-2 adrenoreceptor; BETA2AR; catecholamine receptor
Gene Symbols: ADRB2
Molecular weight: 46,459 Da
Basal Isoelectric point: 6.59  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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