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ADRB2 Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 5q32
Cellular Component: apical plasma membrane; clathrin-coated vesicle membrane; early endosome; endosome; endosome membrane; integral component of plasma membrane; lysosome; membrane; nucleus; plasma membrane; receptor complex
Molecular Function: adenylate cyclase binding; amyloid-beta binding; beta2-adrenergic receptor activity; epinephrine binding; norepinephrine binding; potassium channel regulator activity; protein binding; protein complex binding; protein homodimerization activity
Biological Process: activation of transmembrane receptor protein tyrosine kinase activity; adenylate cyclase activation; adenylate cyclase-activating adrenergic receptor signaling pathway; adrenergic receptor signaling pathway; arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; bone resorption; brown fat cell differentiation; cell surface receptor signaling pathway; cell-cell signaling; cellular response to amyloid-beta; diet induced thermogenesis; endosome to lysosome transport; G-protein coupled receptor signaling pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; heat generation; negative regulation of multicellular organism growth; negative regulation of smooth muscle contraction; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure; positive regulation of AMPA receptor activity; positive regulation of autophagosome maturation; positive regulation of bone mineralization; positive regulation of cAMP-dependent protein kinase activity; positive regulation of lipophagy; positive regulation of MAPK cascade; positive regulation of mini excitatory postsynaptic potential; positive regulation of protein kinase A signaling; positive regulation of protein serine/threonine kinase activity; positive regulation of protein ubiquitination; positive regulation of transcription from RNA polymerase II promoter; protein deubiquitination; receptor-mediated endocytosis; regulation of sodium ion transport; response to cold; response to psychosocial stress
Disease: Asthma, Susceptibility To; Obesity
Reference #:  P07550 (UniProtKB)
Alt. Names/Synonyms: ADRB2; ADRB2R; ADRBR; adrenergic, beta-2-, receptor, surface; B2AR; BAR; Beta-2 adrenergic receptor; Beta-2 adrenoceptor; Beta-2 adrenoreceptor; BETA2AR; catecholamine receptor
Gene Symbols: ADRB2
Molecular weight: 46,459 Da
Basal Isoelectric point: 6.59  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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