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SHP-1 an SH2-containing ubiquitously expressed tyrosine-specific protein phosphatase. Plays a key role in hematopoiesis. Directly links growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component: cytoplasm; cytosol; extracellular region; membrane; nucleolus; nucleus
Molecular Function: protein binding; protein kinase binding; protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity
Biological Process: apoptosis; cell differentiation; cell proliferation; G-protein coupled receptor protein signaling pathway; leukocyte migration; negative regulation of peptidyl-tyrosine phosphorylation; neutrophil degranulation; peptidyl-tyrosine phosphorylation; platelet activation; positive regulation of cell proliferation; positive regulation of phosphoinositide 3-kinase cascade; protein amino acid dephosphorylation; T cell costimulation
Reference #:  P29350 (UniProtKB)
Alt. Names/Synonyms: HCP; HCPH; hematopoietic cell phosphatase; Hematopoietic cell protein-tyrosine phosphatase; HPTP1C; protein tyrosine phosphatase, non-receptor type 6; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; PTN6; PTP-1C; PTP1C; PTPN6; SH-PTP1; SHP-1; SHP-1L; SHP1; Tyrosine-protein phosphatase non-receptor type 6
Gene Symbols: PTPN6
Molecular weight: 67,561 Da
Basal Isoelectric point: 7.65  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  IL6 Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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