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ATG16L1 Plays an essential role in autophagy. Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa). Belongs to the WD repeat ATG16 family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Autophagy; Membrane protein, peripheral
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: autophagic vacuole; axoneme; cytosol
Molecular Function: GTPase binding; identical protein binding; protein binding; small conjugating protein ligase activity
Biological Process: autophagic vacuole formation; macroautophagy
Disease: Inflammatory Bowel Disease 10
Reference #:  Q676U5 (UniProtKB)
Alt. Names/Synonyms: A16L1; APG16 autophagy 16-like; APG16-like 1; APG16L; APG16L beta; ATG16; ATG16 autophagy related 16-like 1 (S. cerevisiae); ATG16 autophagy related 16-like protein 1; ATG16L; ATG16L1; Autophagy-related protein 16-1; FLJ00045; FLJ10035; FLJ10828; FLJ22677; IBD10; WD repeat domain 30; WDR30
Gene Symbols: ATG16L1
Molecular weight: 68,265 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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