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Protein Page:
CD13

Overview
CD13 Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types including small intestinal and tubular epithelial cells, macrophages, granulocytes and synaptic membranes from the CNS. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection. Belongs to the peptidase M1 family. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.11.2; Membrane protein, integral; Other Amino Acids Metabolism - glutathione; Protease; Receptor, misc.
Chromosomal Location of Human Ortholog: 15q26.1
Cellular Component: endoplasmic reticulum-Golgi intermediate compartment; external side of plasma membrane; extracellular space; integral component of membrane; lysosomal membrane; nucleus; plasma membrane; secretory granule membrane
Molecular Function: aminopeptidase activity; metallopeptidase activity; peptide binding; receptor activity; viral receptor activity; zinc ion binding
Biological Process: angiogenesis; cell differentiation; cell-cell signaling; entry of virus into host cell; neutrophil degranulation; peptide catabolic process; proteolysis; regulation of blood pressure; signal transduction
Reference #:  P15144 (UniProtKB)
Alt. Names/Synonyms: alanyl (membrane) aminopeptidase; Alanyl aminopeptidase; Aminopeptidase M; Aminopeptidase N; AMPN; ANPEP; AP-M; AP-N; APN; CD13; gp150; hAPN; LAP1; Microsomal aminopeptidase; Myeloid plasma membrane glycoprotein CD13; P150; PEPN
Gene Symbols: ANPEP
Molecular weight: 109,540 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CD13

Protein Structure Not Found.
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