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METAP2 Removes the N-terminal methionine from nascent proteins. The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. Interacts strongly with the eIF-2 gamma-subunit EIF2S3. Binds EIF2S1 at low magnesium concentrations. Belongs to the peptidase M24A family. Note: This description may include information from UniProtKB.
Protein type: EC; Protease
Chromosomal Location of Human Ortholog: 12q22
Cellular Component: cytoplasm; cytosol; plasma membrane
Molecular Function: aminopeptidase activity; metalloexopeptidase activity; RNA binding
Biological Process: N-terminal protein amino acid modification; peptidyl-methionine modification; protein processing; regulation of rhodopsin mediated signaling
Reference #:  P50579 (UniProtKB)
Alt. Names/Synonyms: AMPM2; eIF-2-associated p67 homolog; Initiation factor 2-associated 67 kDa glycoprotein; MAP 2; MAP2; MetAP 2; METAP2; Methionine aminopeptidase 2; methionyl aminopeptidase 2; MNPEP; p67; P67EIF2; Peptidase M 2
Gene Symbols: METAP2
Molecular weight: 52,892 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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