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ITGAV The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Belongs to the integrin alpha chain family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q32.1
Cellular Component: cell surface; cytosol; external side of plasma membrane; filopodium membrane; focal adhesion; integral component of plasma membrane; integrin complex; membrane; microvillus membrane; phagocytic vesicle; plasma membrane
Molecular Function: C-X3-C chemokine binding; coreceptor activity; extracellular matrix binding; fibroblast growth factor binding; fibronectin binding; insulin-like growth factor I binding; metal ion binding; opsonin binding; peptide binding; protease binding; protein binding; protein kinase C binding; receptor binding; transforming growth factor beta binding; viral receptor activity; voltage-gated calcium channel activity
Biological Process: angiogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; apoptotic cell clearance; cell adhesion; cell adhesion mediated by integrin; cell growth; cell migration; cell-matrix adhesion; cell-substrate adhesion; elevation of cytosolic calcium ion concentration; entry of symbiont into host cell by promotion of host phagocytosis; entry of virus into host cell; extracellular matrix organization; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; leukocyte migration; negative chemotaxis; negative regulation of lipid transport; negative regulation of lipoprotein metabolic process; negative regulation of low-density lipoprotein receptor biosynthetic process; neutrophil degranulation; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of MAPK cascade; positive regulation of osteoblast proliferation; regulation of phagocytosis; vascular endothelial growth factor receptor signaling pathway; vasculogenesis
Reference #:  P06756 (UniProtKB)
Alt. Names/Synonyms: antigen identified by monoclonal antibody L230; CD51; DKFZp686A08142; Integrin alpha-V; Integrin alpha-V heavy chain; Integrin alpha-V light chain; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); ITAV; ITGAV; MSK8; Vitronectin receptor subunit alpha; VNRA
Gene Symbols: ITGAV
Molecular weight: 116,038 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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