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BAZ1A Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end- positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression. Component of the ACF chromatin remodeling complex that includes BAZ1A and SMARCA5. Additional this complex can form, together with CHRAC1 and POLE1, the histone-fold protein complex, CHRAC. Interacts with NCOR1 (via its RD1 domain); the interaction corepresses a number of NCOR1-regulated genes. Highly expressed in testis and at low or undetectable levels in other tissues analyzed. Belongs to the WAL family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; BAZ family; DNA replication; DNA-binding; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 14q13.1-q13.2
Cellular Component: chromatin accessibility complex
Molecular Function: histone acetyltransferase activity; protein binding
Biological Process: chromatin remodeling; DNA-dependent DNA replication
Reference #:  Q9NRL2 (UniProtKB)
Alt. Names/Synonyms: ACF1; ATP-dependent chromatin remodeling protein; ATP-dependent chromatin-remodeling protein; ATP-utilizing chromatin assembly and remodeling factor 1; BAZ1A; Bromodomain adjacent to zinc finger domain protein 1A; bromodomain adjacent to zinc finger domain, 1A; CHRAC subunit ACF1; DKFZp586E0518; FLJ14383; hACF1; hWALp1; WALp1; WCRF180; Williams syndrome transcription factor-related chromatin-remodeling factor 180
Gene Symbols: BAZ1A
Molecular weight: 178,702 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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