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CDC25A a member of the MPI phosphatase family. Functions as a dosage-dependent inducer in mitotic control.. Required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: cytosol; nucleoplasm
Molecular Function: chaperone binding; phosphoprotein phosphatase activity; protein binding; protein kinase binding
Biological Process: cell proliferation; DNA replication; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; protein deubiquitination; regulation of cell cycle; regulation of cyclin-dependent protein kinase activity; response to radiation
Reference #:  P30304 (UniProtKB)
Alt. Names/Synonyms: CDC25A; CDC25A2; cell division cycle 25 homolog A (S. pombe); cell division cycle 25A; Dual specificity phosphatase Cdc25A; M-phase inducer phosphatase 1; MPIP1
Gene Symbols: CDC25A
Molecular weight: 59,087 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  G2/M DNA Damage Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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