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eIF2B-epsilon eukaryotic translation initiation factor 2B, subunit 5. A translational regulatory protein that functions in the early steps of protein synthesis by catalyzing the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Mutation in EIF2B5 causes childhood ataxia with central nervous system hypomyelination/ vanishing white matter leukodystrophy. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: 3q27.1
Cellular Component: cytoplasm; cytosol; eukaryotic translation initiation factor 2B complex; nucleus
Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; translation initiation factor activity; translation initiation factor binding
Biological Process: astrocyte development; astrocyte differentiation; myelination; negative regulation of translation initiation in response to stress; oligodendrocyte development; ovarian follicle development; positive regulation of translational initiation; response to glucose stimulus; response to heat; response to peptide hormone stimulus; translational initiation
Disease: Leukoencephalopathy With Vanishing White Matter
Reference #:  Q13144 (UniProtKB)
Alt. Names/Synonyms: CACH; CLE; EI2BE; EIF-2B; eIF-2B GDP-GTP exchange factor subunit epsilon; EIF2B5; EIF2BE; EIF2Bepsilon; eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa; LVWM; Translation initiation factor eIF-2B subunit epsilon
Gene Symbols: EIF2B5
Molecular weight: 80,380 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF2  |  Translational Control
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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