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TRADD Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD, HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP. Found in all examined tissues. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Apoptosis
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: cytoplasm; cytoskeleton; cytosol; membrane raft; nucleus; plasma membrane; receptor complex
Molecular Function: identical protein binding; kinase binding; molecular adaptor activity; protein binding; protein complex binding; signal transducer activity; tumor necrosis factor receptor binding
Biological Process: activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptosis; I-kappaB kinase/NF-kappaB signaling; induction of apoptosis via death domain receptors; positive regulation of apoptosis; positive regulation of hair follicle development; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; protein heterooligomerization; signal transduction; tumor necrosis factor-mediated signaling pathway
Reference #:  Q15628 (UniProtKB)
Alt. Names/Synonyms: Hs.89862; MGC11078; TNFR1-associated DEATH domain protein; TNFRSF1A-associated via death domain; TRADD; tumor necrosis factor receptor type 1 associated death domain protein; Tumor necrosis factor receptor type 1-associated DEATH domain protein; tumor necrosis factor receptor-1-associated protein
Gene Symbols: TRADD
Molecular weight: 34,247 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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