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Protein Page:
PGC-1 alpha

PGC-1 alpha a transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor genes. Interacts with, and regulates the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). Regulates many genes involved in energy metabolism. Provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. May be involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. Its transcription is repressed by ZNF746 which binds to 'insulin response sequences' in its promoter. Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 4p15.2
Cellular Component: DNA-directed RNA polymerase II, core complex; intracellular membrane-bound organelle; nucleoplasm; nucleus
Molecular Function: chromatin DNA binding; DNA binding; ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; protein binding; RNA binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor binding; ubiquitin protein ligase binding
Biological Process: brown fat cell differentiation; cellular respiration; circadian regulation of gene expression; circadian rhythm; digestion; mitochondrion organization and biogenesis; mRNA processing; negative regulation of neuron apoptosis; positive regulation of fatty acid oxidation; positive regulation of gluconeogenesis; positive regulation of histone acetylation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein complex assembly; protein stabilization; regulation of circadian rhythm; regulation of transcription, DNA-dependent; response to muscle activity; RNA splicing; thermoregulation; transcription initiation from RNA polymerase II promoter
Reference #:  Q9UBK2 (UniProtKB)
Alt. Names/Synonyms: LEM6; Ligand effect modulator 6; ligand effect modulator-6; peroxisome proliferative activated receptor, gamma, coactivator 1, alpha; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; PGC-1(alpha); PGC-1-alpha; PGC-1v; PGC1; PGC1A; PPAR gamma coactivator variant form; PPAR gamma coactivator-1; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; PPARGC1; PPARGC1A; PRGC1
Gene Symbols: PPARGC1A
Molecular weight: 91,027 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  mTOR Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PGC-1 alpha

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