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TNIP1 Interacts with zinc finger protein A20/TNFAIP3 and inhibits TNF-induced NF-kappa-B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal; however, binding to A20/TNFAIP3 seems not to be required for this function. Inhibits NF-kappa-B activation by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcricption. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflamation; this function is mediated by association with SELPLG and dependent on phosohorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. Interacts with TNFAIP3 and IKBKG; facilitates TNFAIP3- mediated de-ubiquitination of NEMO/IKBKG. Interacts with HIV-1 matrix protein. Interacts with Shigella flexneri ipah9.8; the interaction promotes polyubiquitination of IKBKG. Interacts with polyubiquitin. Interacts with MAPK1, SELPLG and PIK3CD. Interacts with IKBKG (polyubiquitinated). Interacts with IRAK1 (polyubiquitinated). Interacts with MYD88; the interaction is indicative for participation in an activated TLR-signaling complex. Ubiquitous. Strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription regulation
Chromosomal Location of Human Ortholog: 5q33.1
Cellular Component: cytoplasm; cytosol; intracellular; nucleoplasm
Molecular Function: identical protein binding; mitogen-activated protein kinase binding; polyubiquitin binding; protein binding
Biological Process: defense response; glycoprotein biosynthetic process; leukocyte adhesion; MyD88-dependent toll-like receptor signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of viral genome replication; positive regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter; protein deubiquitination; translation
Reference #:  Q15025 (UniProtKB)
Alt. Names/Synonyms: ABIN-1; HIV-1 Nef-interacting protein; hVAN; KIAA0113; NAF1; Nef-associated factor 1; Nef-associated factor 1 SNP; Nip40-1; TNFAIP3 interacting protein 1; TNFAIP3-interacting protein 1; TNIP1; VAN; Virion-associated nuclear shuttling protein; virion-associated nuclear-shuttling protein
Gene Symbols: TNIP1
Molecular weight: 71,864 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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