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HSP90A a molecular chaperone of the heat shock protein 90 family. Has ATPase activity. Known to interact with a wide variety of proteins including steroid hormone receptors, neuropeptide Y, FKBP51/54, and FKBP52. G protein-coupled receptor kinases are stabilized by interacting with HSP 90. Hsp70 and Hsp90 promote tau solubility and tau binding to microtubules, reducing insoluble tau phosphorylation of tau. Note: This description may include information from UniProtKB.
Protein type: Chaperone; Heat shock protein
Chromosomal Location of Human Ortholog: 14q32.31
Cellular Component: cytoplasm; cytosol; extracellular region; lysosomal lumen; membrane; nucleoplasm; nucleus; plasma membrane; protein complex
Molecular Function: ATP binding; ATPase activity; GTPase binding; histone deacetylase binding; identical protein binding; nitric-oxide synthase regulator activity; nucleotide binding; protein binding; protein homodimerization activity; protein-tyrosine kinase activity; RNA binding; TPR domain binding
Biological Process: chaperone-mediated protein complex assembly; G2/M transition of mitotic cell cycle; mitochondrial transport; neutrophil degranulation; positive regulation of nitric oxide biosynthetic process; positive regulation of telomerase activity; protein import into mitochondrial outer membrane; protein refolding; protein stabilization; receptor-mediated endocytosis; regulation of nitric-oxide synthase activity; regulation of protein ubiquitination; response to antibiotic; response to cold; response to heat; telomere maintenance via telomerase; vascular endothelial growth factor receptor signaling pathway
Reference #:  P07900 (UniProtKB)
Alt. Names/Synonyms: FLJ31884; Heat shock 86 kDa; heat shock 90kD protein 1, alpha; heat shock 90kD protein 1, alpha-like 4; heat shock 90kD protein, alpha-like 4; heat shock 90kDa protein 1, alpha; heat shock protein 90kDa alpha (cytosolic), class A member 1; Heat shock protein HSP 90-alpha; HS90A; HSP 86; HSP86; Hsp89; HSP89A; Hsp90; HSP90A; HSP90AA1; HSP90N; HSPC1; HSPCA; HSPCAL1; HSPCAL4; HSPN; LAP2; Renal carcinoma antigen NY-REN-38
Gene Symbols: HSP90AA1
Molecular weight: 84,660 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Inhibition of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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