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EGR1 Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation. By growth factors. Belongs to the EGR C2H2-type zinc-finger protein family. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 5q31.2
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: DNA binding; double-stranded methylated DNA binding; histone acetyltransferase binding; protein binding; sequence-specific DNA binding; transcription factor activity; zinc ion binding
Biological Process: positive regulation of chemokine biosynthetic process; positive regulation of hormone biosynthetic process; positive regulation of interleukin-1 beta biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of protein sumoylation; response to hypoxia; transcription from RNA polymerase II promoter
Reference #:  P18146 (UniProtKB)
Alt. Names/Synonyms: AT225; early growth response 1; Early growth response protein 1; EGR-1; EGR1; G0S30; KROX-24; KROX24; Nerve growth factor-induced protein A; NGFI-A; TIS8; Transcription factor ETR103; Transcription factor Zif268; ZIF-268; Zinc finger protein 225; Zinc finger protein Krox-24; ZNF225
Gene Symbols: EGR1
Molecular weight: 57,507 Da
Basal Isoelectric point: 8.51  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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