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ITGAM a single-pass type I membrane protein of the integrin alpha chain family. Implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. Also known as CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. A receptor for fibrinogen, factor X and ICAM1. Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Predominantly expressed in monocytes and granulocytes. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: cell surface; external side of plasma membrane; extracellular space; integrin complex; plasma membrane
Molecular Function: complement component C3b binding; heat shock protein binding; metal ion binding; protein binding; protein heterodimerization activity
Biological Process: cell adhesion; extracellular matrix organization; integrin-mediated signaling pathway; leukocyte migration; microglial cell activation; negative regulation of dopamine metabolic process; neutrophil degranulation; phagocytosis, engulfment; positive regulation of superoxide anion generation; toll-like receptor 4 signaling pathway
Disease: Systemic Lupus Erythematosus, Susceptibility To, 6
Reference #:  P11215 (UniProtKB)
Alt. Names/Synonyms: antigen CD11b (p170); CD11 antigen-like family member B; CD11B; Cell surface glycoprotein MAC-1 subunit alpha; CR-3 alpha chain; CR3A; Integrin alpha-M; integrin, alpha M (complement component 3 receptor 3 subunit); ITAM; ITGAM; Leukocyte adhesion receptor MO1; MAC-1; MAC1A; macrophage antigen alpha polypeptide; MGC117044; MO1A; Neutrophil adherence receptor; neutrophil adherence receptor alpha-M subunit; SLEB6
Gene Symbols: ITGAM
Molecular weight: 127,179 Da
Basal Isoelectric point: 6.88  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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