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CCND1 a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Note: This description may include information from UniProtKB.
Protein type: Activator; Cell cycle regulation; Nuclear receptor co-regulator; Oncoprotein
Chromosomal Location of Human Ortholog: 11q13.3
Cellular Component: cyclin-dependent protein kinase holoenzyme complex; cytosol; intracellular; nucleoplasm; nucleus; transcriptional repressor complex
Molecular Function: cyclin-dependent protein kinase activity; enzyme binding; histone deacetylase binding; protein binding; protein kinase binding; transcription corepressor activity; transcription factor binding
Biological Process: G1 DNA damage checkpoint; G1/S transition of mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell cycle; positive regulation of cyclin-dependent protein kinase activity; positive regulation of protein amino acid phosphorylation; response to DNA damage stimulus; response to drug
Disease: Myeloma, Multiple; Von Hippel-lindau Syndrome
Reference #:  P24385 (UniProtKB)
Alt. Names/Synonyms: B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; BCL1; CCND1; CycD1; cyclin D1; D11S287E; G1/S-specific cyclin D1; G1/S-specific cyclin-D1; PRAD1; PRAD1 oncogene; U21B31
Gene Symbols: CCND1
Molecular weight: 33,729 Da
Basal Isoelectric point: 4.97  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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