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CCNB1 a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Complexes with cdc2 to form the maturation-promoting factor (MPF). Two alternatively spliced isoforms have been found, a constitutively expressed form and a cell cycle-regulated form that is expressed predominantly during G2/M phase. Note: This description may include information from UniProtKB.
Protein type: Activator; Cell cycle regulation
Chromosomal Location of Human Ortholog: 5q13.2
Cellular Component: centrosome; cytoplasm; cytosol; mitochondrial matrix; nucleoplasm; nucleus; spindle pole
Molecular Function: cyclin-dependent protein kinase activity; patched binding; protein binding; protein kinase binding
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G2/M transition of mitotic cell cycle; G2/M-specific positive regulation of cyclin-dependent protein kinase activity; mitotic metaphase plate congression; mitotic nuclear envelope disassembly; mitotic spindle organization and biogenesis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of attachment of spindle microtubules to kinetochore; positive regulation of mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle
Reference #:  P14635 (UniProtKB)
Alt. Names/Synonyms: CCNB; CCNB1; cyclin B1; G2/mitotic-specific cyclin B1; G2/mitotic-specific cyclin-B1
Gene Symbols: CCNB1
Molecular weight: 48,337 Da
Basal Isoelectric point: 7.09  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  G2/M DNA Damage Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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