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C/EBP-beta a bZIP transcription factor which can form homodimers or heterodimers with the related proteins CEBP-alpha, -delta and -gamma. Involved in immune and inflammatory responses. Specifically binds to regulatory regions of genes encoding IL-6, other cytokines and several acute-phase proteins. There are two forms of C/EBPbeta, the 38kDa liver activating protein (LAP) and the 20kDa liver inhibitory protein (LIP) which may be products of alternative translation. LAP is a transcriptional activator while LIP may inhibit C/EBPbeta transcriptional activity. Phosphorylated and activated by ERK1/2. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Transcription factor
Chromosomal Location of Human Ortholog: 20q13.13
Cellular Component: nucleoplasm; nucleus
Molecular Function: DNA binding; protein binding; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding
Biological Process: acute-phase response; defense response to bacterium; immune response; inflammatory response; negative regulation of T cell proliferation; ovarian follicle development; positive regulation of fat cell differentiation; positive regulation of interleukin-4 production; positive regulation of transcription from RNA polymerase II promoter; regulation of osteoclast differentiation; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter
Reference #:  P17676 (UniProtKB)
Alt. Names/Synonyms: C/EBP beta; C/EBP-beta; CCAAT/enhancer binding protein (C/EBP), beta; CCAAT/enhancer-binding protein beta; CEBPB; CRP2; IL6DBP; interleukin 6-dependent DNA-binding protein; LAP; Liver activator protein; liver-enriched transcriptional activator protein; MGC32080; NF-IL6; Nuclear factor NF-IL6; nuclear factor of interleukin 6; TCF-5; TCF5; Transcription factor 5
Gene Symbols: CEBPB
Molecular weight: 36,106 Da
Basal Isoelectric point: 8.55  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Growth And Differentiation Control by MAPKs  |  Wnt/ß-Catenin Signaling
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