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PRDM1 a transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene and can inhibit virus-mediated IFN-¿ production. Recruits chromatin-modifying enzymes including histone deacetylases and methyltransferases. Drives the maturation of B-lymphocytes into Ig secreting cells. Interacts with PRMT5. Expression of Blimp-1 is sufficient to drive terminal differentiation of BCL1 lymphoma cells into antibody secreting plasma cells, increasing the expression of the cell surface marker Syndecan-1. In the B-cell lineage, Blimp-1 is specifically expressed in antibody-secreting cells including activated B and plasma cells. In addition, Blimp-1 has been found during macrophage differentiation and in a subset of T-cells suggesting that it may play a wider role in homeostasis and differentiation. Target genes of Blimp-1 transcriptional repression with potential roles in differentiation include c-Myc, CIITA, Pax5, Spi-B, and Id3.Three isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Methyltransferase, protein lysine, predicted; Transcription regulation; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: cytoplasm; nucleoplasm
Molecular Function: protein binding; transcription factor activity
Biological Process: negative regulation of transcription from RNA polymerase II promoter; regulation of extrathymic T cell differentiation; regulation of natural killer cell differentiation; regulation of NK T cell differentiation
Reference #:  O75626 (UniProtKB)
Alt. Names/Synonyms: B-lymphocyte-induced maturation protein 1; Beta-interferon gene positive regulatory domain I-binding factor; beta-interferon gene positive-regulatory domain I binding factor; BLIMP-1; BLIMP1; MGC118922; MGC118923; MGC118924; MGC118925; Positive regulatory domain I-binding factor 1; PR domain containing 1, with ZNF domain; PR domain zinc finger protein 1; PR domain-containing protein 1; PR-domain zinc finger protein 1; PRDI-BF1; PRDI-binding factor 1; PRDI-binding factor-1; PRDM1
Gene Symbols: PRDM1
Molecular weight: 91,771 Da
Basal Isoelectric point: 8.76  Predict pI for various phosphorylation states
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