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CTCF a widely expressed, sequence-specific DNA-binding transcriptional regulator, insulator, and organizer of higher-order chromatin structure. Acts as a tumor suppressor. Contains 11 C2H2-type zinc fingers. Involved in promoter activation or repression, hormone-responsive gene silencing, methylation-dependent chromatin insulation, and genomic imprinting. Mediates pairing between X chromosomes and interactions between distant regulatory elements. Binds to promoters of c-myc, PLK, PIM1 and APP. A critical regulator of cell-cycle arrest and death after B cell receptor signaling in immature B cells. CTCF, together with YY1 and Tsix, form a regulated epigenetic switch for X-inactivation. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Transcription factor; Tumor suppressor
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: chromosome, pericentric region; condensed chromosome; nucleolus; nucleoplasm; nucleus
Molecular Function: chromatin insulator sequence binding; protein binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity; zinc ion binding
Biological Process: negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nucleosome positioning; positive regulation of transcription, DNA-dependent; regulation of gene expression, epigenetic; regulation of molecular function, epigenetic
Disease: Mental Retardation, Autosomal Dominant 21
Reference #:  P49711 (UniProtKB)
Alt. Names/Synonyms: 11 zinc finger transcriptional repressor; 11-zinc finger protein; CCCTC-binding factor; CCCTC-binding factor (zinc finger protein); CTCF; CTCFL paralog; Transcriptional repressor CTCF
Gene Symbols: CTCF
Molecular weight: 82,785 Da
Basal Isoelectric point: 6.51  Predict pI for various phosphorylation states
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