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ATF-4 a leucine zipper transcription factor that was isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). Involved in the unfolded protein response (UPR) in which dietary protein deficiency, imbalanced amino acid intake via the amino acid response, or ER stress activate the EIF2AK3-eIF2-ATF4 pathway. In concert with DDIT3, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors. Involved in cisplatin resistance. Other members of the family include AP-1 transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. A member of the bZIP family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: cytoplasm; neuron projection; nucleoplasm; nucleus
Molecular Function: DNA binding; leucine zipper domain binding; protein binding; sequence-specific DNA binding; transcription factor activity
Biological Process: amino acid metabolic process; cellular response to amino acid starvation; cellular response to glucose starvation; circadian regulation of gene expression; gluconeogenesis; mRNA transcription from RNA polymerase II promoter; negative regulation of translation initiation in response to stress; positive regulation of apoptosis; positive regulation of neuron apoptosis; positive regulation of transcription from RNA polymerase I promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter
Reference #:  P18848 (UniProtKB)
Alt. Names/Synonyms: Activating transcription factor 4; activating transcription factor 4 (tax-responsive enhancer element B67); ATF4; cAMP response element-binding protein 2; cAMP-dependent transcription factor ATF-4; cAMP-responsive element-binding protein 2; CREB-2; CREB2; Cyclic AMP-dependent transcription factor ATF-4; Cyclic AMP-responsive element-binding protein 2; DNA-binding protein TAXREB67; Tax-responsive enhancer element-binding protein 67; TaxREB67; TXREB
Gene Symbols: ATF4
Molecular weight: 38,590 Da
Basal Isoelectric point: 4.83  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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