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Caldesmon a cytoskeletal protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells. May act as a bridge between myosin and actin filaments. Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Five alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Actin-binding
Chromosomal Location of Human Ortholog: 7q33
Cellular Component: actin cytoskeleton; cytoskeleton; cytosol; intracellular membrane-bound organelle; plasma membrane
Molecular Function: cadherin binding; protein binding; tropomyosin binding
Biological Process: cell motility; muscle contraction
Reference #:  Q05682 (UniProtKB)
Alt. Names/Synonyms: CAD; CALD1; Caldesmon; caldesmon 1; CDM; H-CAD; HCAD; L-CAD; LCAD; MGC21352; NAG22
Gene Symbols: CALD1
Molecular weight: 93,231 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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