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RHOC a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1p13.2
Cellular Component: cleavage furrow; cytosol; plasma membrane; stereocilium
Molecular Function: protein binding; signal transducer activity
Biological Process: apical junction assembly; cytokinesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of lipase activity; positive regulation of protein homooligomerization; regulation of small GTPase mediated signal transduction
Reference #:  P08134 (UniProtKB)
Alt. Names/Synonyms: ARH9; ARHC; h9; MGC1448; MGC61427; oncogene RHO H9; ras homolog gene family, member C; RAS-related homolog 9; Rho cDNA clone 9; Rho-related GTP-binding protein RhoC; RHOC; rhoC GTPase; RHOH9; small GTP binding protein RhoC
Gene Symbols: RHOC
Molecular weight: 22,006 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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