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Protein Page:

RHOB a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Tumor suppressor
Chromosomal Location of Human Ortholog: 2p24.1
Cellular Component: cleavage furrow; cytosol; endosome membrane; focal adhesion; nucleus; plasma membrane
Molecular Function: GTP binding; GTPase activity; protein binding
Biological Process: apoptosis; cell adhesion; cytokinesis; endosome to lysosome transport; negative regulation of cell cycle; negative regulation of cell migration; platelet activation; positive regulation of angiogenesis; positive regulation of apoptosis; regulation of cell migration; regulation of small GTPase mediated signal transduction; Rho protein signal transduction
Reference #:  P62745 (UniProtKB)
Alt. Names/Synonyms: Aplysia RAS-related homolog 6; ARH6; ARHB; h6; MST081; MSTP081; oncogene RHO H6; ras homolog gene family, member B; Rho cDNA clone 6; Rho-related GTP-binding protein RhoB; RHOB; RHOH6
Gene Symbols: RHOB
Molecular weight: 22,123 Da
Basal Isoelectric point: 5.1  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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