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PAK1 a protein kinase of the STE20 family that regulates cell motility and morphology. Critical RhoGTPase effector that regulates cytoskeleton reorganization, the JNK MAPK pathway, and nuclear signaling. Binding of Rac/cdc42 to the PBD of PAK1 causes autophosphorylation and conformational change. Phosphorylated and activated by PDK. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; PAKA subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of Human Ortholog: 7 E1|7 53.57 cM
Cellular Component: axon; cytoplasm; cytosol; dendrite; focal adhesion; growth cone; intercellular junction; lamellipodium; membrane; nuclear membrane; nucleus; plasma membrane; postsynaptic density; protein complex; ruffle; Z disc
Molecular Function: collagen binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; Rac GTPase binding
Biological Process: actin cytoskeleton organization and biogenesis; actin cytoskeleton reorganization; activation of protein kinase activity; amygdala development; branching morphogenesis of a tube; cell migration; cellular response to insulin stimulus; dendrite development; establishment of cell polarity; hepatocyte growth factor receptor signaling pathway; neurite morphogenesis; neuromuscular junction development; positive regulation of axon extension; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of estrogen receptor signaling pathway; positive regulation of JNK activity; positive regulation of microtubule polymerization; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of stress fiber formation; protein amino acid autophosphorylation; protein amino acid phosphorylation; receptor clustering; regulation of actin cytoskeleton organization and biogenesis; regulation of apoptosis; regulation of axonogenesis; regulation of gene expression; regulation of MAPKKK cascade; regulation of mitotic cell cycle; response to hypoxia; response to organic substance; Rho protein signal transduction; stress-activated protein kinase signaling pathway; wound healing
Reference #:  O88643 (UniProtKB)
Alt. Names/Synonyms: activated protein kinase alpha; Alpha-PAK; AW045634; CDC42/RAC effector kinase PAK-A; OTTMUSP00000023295; p21 protein (Cdc42/Rac)-activated kinase 1; p21-activated kinase 1; p65-PAK; PAK-1; Pak1; Paka; Serine/threonine-protein kinase PAK 1
Gene Symbols: Pak1
Molecular weight: 60,737 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Microtubule Dynamics  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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