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VEGFR1 a receptor tyrosine kinase of the VEGFR family. Receptor for VEGF, VEGFB and PGF. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Two splice variant isoforms have been described. Isoform SFlt1 may have an inhibitory role in angiogenesis. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; VEGFR family
Chromosomal Location of Human Ortholog: 13q12.3
Cellular Component: actin cytoskeleton; extracellular space; focal adhesion; integral to plasma membrane; plasma membrane; receptor complex
Molecular Function: growth factor binding; protein binding; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor receptor activity
Biological Process: blood vessel morphogenesis; cell migration; embryonic morphogenesis; monocyte chemotaxis; peptidyl-tyrosine phosphorylation; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of MAP kinase activity; positive regulation of MAPKKK cascade; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of vascular endothelial growth factor receptor signaling pathway; protein amino acid autophosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway
Reference #:  P17948 (UniProtKB)
Alt. Names/Synonyms: FLT; FLT-1; FLT1; Fms-like tyrosine kinase 1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); FRT; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; Vascular endothelial growth factor receptor 1; Vascular permeability factor receptor; VEGFR-1; VEGFR1; VGFR1
Gene Symbols: FLT1
Molecular weight: 150,769 Da
Basal Isoelectric point: 8.66  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
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